![]() ![]() I believe this treatment approach may place your patient at significant risk. I would be very skeptical that this would have any value as antihistamine therapy does not usually prevent systemic IgE mediated reactions as mast cells release many factors other than histamine. ![]() I am not sure if you are referring to antihistamine therapy to suppress symptoms to allow ingestion and the development of tolerance. I am not aware of a “one month antihistamine treatment” for such allergy. Spices do show some cross reactivity (see abstracts and references below) but the clinical significance of these findings are difficult to confirm as allergy to spices is rare.Ĭertainly testing does not have a 100% negative predictive value as foods are modified by digestion and I do not know if you tested with fresh or processed ginger. I would try to obtain the exact components of the ginger juice and the curry to which he reacted to see if you could identify a common agent. The combination of reactions to two complex mixtures would make me suspicious of a common ingredient. Curry, which includes curry powder or spice, is also a complex mixture of ingredients with great variability (see Ask The Expert question from archives). If his in vitro IgE and prick skin test to ginger is negative, I would be concerned that another ingredient is responsible for his acute symptoms, especially since he is also having symptoms with curry. It would be helpful to know the specific ingredients in the “ginger” juice your patient was drinking. Ginger juice is a term used for a variety of drinks that contain multiple ingredients in addition to ginger. ![]()
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